The emergence of the importance of such phenomena as alternative RNA processing, regulatory RNAs, and RNA-mediated enzymatic mechanisms to the regulation of gene expression in cells, along with the recognition of the contributions of RNA to disease pathogenesis and normal development, have made an understanding of the field of RNA biology essential to all life science disciplines. It is the goal of WIREs RNA to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
随着RNA替代RNA处理,调节RNA和RNA介导的酶促机制等现象对细胞中基因表达调控的重要性的出现,以及RNA对疾病发病机制和正常发育的贡献的认识,已经成为了解所有生命科学学科必不可少的RNA生物学领域。 WIREs RNA的目标是为这个有趣且不断发展的领域提供全面,最新和连贯的报道,为RNA专家和跨学科研究人员提供框架,不仅可以获得RNA生物学领域的观点,而且可以产生新的见解和应用程序。主要议题包括:RNA结构和动力学; RNA进化和基因组学;基于RNA的催化; RNA与蛋白质和其他分子的相互作用;翻译; RNA加工; RNA出口/本地化; RNA转换和监测;调节RNA / RNAi /核糖开关;疾病与发展中的RNA;和RNA方法。
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